Representative Publications
1. Feng, H.╪; Zhao, Q.╪; Zhao, N.; Liang, Z.; Huang, Y.; Zhang, X.; Zhang, L.*; Liu, Y.*; A Cell-Permeable Photosensitizer for Selective Proximity Labeling and Crosslinking of Aggregated Proteome. Adv. Sci. 2024, Accepted. DOI: 10.1002/advs.202306950.
2. Shen, D.╪; Zhao, Q.╪; Wang, M.; Zhong, Bo.; Jin, W.; Huang, Y.; Jin, H.; Jing, B.; Wan, W.; Zhang, X.; Zhang, L.*; Liu, Y.*; Developing an Affinity‐based Chemical Proteomics Method to in‐situ Capture Amorphous Aggregated Proteome and Profile its Heterogeneity in Stressed Cells. Anal. Chem. 2023, 95, 15, 6358–6366.
3. Feng, H.╪; Zhao, Q.╪; Zhang, B.; Hu, H.; Liu, M.; Wu, K.; Li, X.; Zhang, X.*; Zhang, L.*; Liu, Y.*; Enabling Photo-Crosslinking and Photo-Sensitizing Properties for Synthetic Fluorescent Protein Chromophores. Angew. Chem. Int. Ed. 2023, 62, e202215215.
4. Wan, W.╪; Zeng, L.╪; Jin, W.; Chen, X.; Shen, D.; Huang, Y.; Wang, M.; Bai, Y.; Lyu, H.; Dong, X.; Gao, Z.; Wang, L.; Liu, X.; Liu, Y.*; A Solvatochromic Fluorescent Probe Reveals Polarity Heterogeneity upon Protein Aggregation in Cells. Angew. Chem. Int. Ed. 2021, 60, 25865-25871.
5. Shen, D.; Jin, W.; Bai, Y.; Huang, Y.; Lyu, H.; Zeng, L.; Wang, M.; Tang, Y.; Wan, W.; Dong, X.; Gao, Z.; Piao, H.; Liu, X.; Liu, Y.*; Rational Design of Crystallization Induced Emission Probes to Detect Amorphous Protein Aggregation in Live Cells. Angew. Chem. Int. Ed. 2021, 60, 16067-16076.
6. Wan, W.; Huang, Y.; Xia, Q.; Bai, Y.;Jin, W.;Wang, M.; Lyu, H.; Tang, Y.; Dong, X.; Gao, Z.; Zhao, Q.; Zhang, L.; Liu, Y.*; Covalent Probes for Aggregated Protein Imaging via Michael Addition. Angew. Chem. Int. Ed. 2021, 60, 11335-11343.(Hot paper)
7. Bai, Y.; Wan, W.*; Huang, Y.; Jin, W.; Lyu, H.; Xia, Q.; Dong, X.; Gao, Z.; Liu, Y.*; Quantitative Interrogation of Protein Co‐aggregation using Multicolor Fluorogenic Protein Aggregation Sensors. Chem.Sci. 2021, 12, 8468–8476. (Most popular 2021 chemical biology articles)
2024
(75) Transthyretin Amyloid Cardiomyopathy with T59K Mutation: A Case Report of a Chinese Patient with Comprehensive Biochemical Profiles. In submission.
(74) Clinical and Molecular Insights into Homozygous and Heterozygous A97S Variants in Hereditary Transthyretin Amyloid Polyneuropathy in South China. In submission.
(73) Clinical and biochemical characterization of patients and asymptomatic carriers with ATTR V30L. In submission.
(72) Unraveling the Solvent Polarity Effects of a Photo-Uncaging Reaction towards Suborganelle-Targeted Protein Proximity Labeling. In submission.
(71) Chemical Sensors Detect and Resolve Proteome Aggregation in Peripheral Neuropathy Cell Model Induced by Chemotherapeutic Agents. Under review.
(70) An Integrated Imaging and Proteomics Bio-sensing Strategy Reveals Proteome Aggregation Induced by Platinum-based Chemotherapy Drugs via Disturbing Protein Homeostasis. Revised.
(69) Luo, P.╪; Liu, Z.╪; Lai, C.; Jin, Z.; Wang, M.; Zhao, H.; Liu, Y.; Zhang, W.; Wang, X.; Xiao, C.; Yang, X.; Wang, F.*; Time-Resolved Ultraviolet Photodissociation Mass Spectrometry Probes the Mutation-Induced Alterations in Protein Stability and Unfolding Dynamics. J. Am. Chem. Soc. 2024, Accepted.
(68) He, X.╪; Wang, M.╪; Sun, J.; Yu, Z.; Hu, X.; Liu, Y.*; Lin. X.*; Characterization of Transthyretin Mutation G47V Associated with Hereditary Cardiac Amyloidosis. Cardiology. 2024, Accepted. DOI:10.1159/000538081.
(67) Ma, J.╪; Sun, R,╪; Xia, K.╪; Xia, Q.╪; Liu, Y.*; Zhang, X.*; Design and Application of Fluorescent Probes to Detect Cellular Physical Microenvironments. Chem. Rev. 2024, Accepted. DOI: 10.1021/acs.chemrev.3c00573.
(66) Feng, H.╪; Zhao, Q.╪; Zhao, N.; Liang, Z.; Huang, Y.; Zhang, X.; Zhang, L.*; Liu, Y.*; A Cell-Permeable Photosensitizer for Selective Proximity Labeling and Crosslinking of Aggregated Proteome. Adv. Sci. 2024, Accepted. DOI: 10.1002/advs.202306950.
(65) Zhang, Z╪; Dong, X.╪; Wang Wan*; Guo, H.; Sun, R.; Feng, H.; Wang, M.; Wang, Z.; Jin, H.; Sun, J.; Xia, Q.; Zhao, Q.; Shen, D.; Gao, Z.*; Liu,Y.*; Unravelling Intracellular Protein Corona Components of Nanoplas-tics via Photocatalytic Protein Proximity Labeling. Anal. Chem. 2024, Accepted. DOI: 10.1021/acs.analchem.4c00050.
(64) Hoelzel, C.╪; Bai, Y.╪; Wang, M.; Liu, Y.*; Zhang, X*; High-Fidelity Assay Based on Turn-Off Fluorescence to Detect the Perturbations of Cellular Proteostasis. ACS Bio. Med. Chem. Au 2024, Accepted. DOI: 10.1021/acsbiomedchemau.3c00012.
2023
(63) Bai, Y.╪; Zhang, S.╪; Dong, H.╪; Liu, Y.; Liu, C.*; Zhang, X.*; Advanced Techniques for Detecting Protein Misfolding and Aggregation in Cellular Environments. Chem. Rev. 2023, 123, 21, 12254–12311.
(62) Jin, H.╪; Shen, D.╪; Jing, B.; Zhang, Z.; Wang, Z.; Sun, R.; Zhang, H.; Sun, J.; Lyu, H.; Liu, Y.*; Wang, L.*; An epoxide-based covalent sensor to detect cardiac proteome aggregation in a cardio-oncology model. Anal. Chim. Acta. 2023, 1278, 341704.
(61) Jing, B.╪; Wan, W.╪; Hu, B.; Jin, W.; Zhang, Z.; Peng, C.; Wang, M.; Deng, J.; Dong, X.; Liu, Y.*; Gao, Z.*; Plastic nanoparticles cause proteome stress and aggregation by compromising cellular protein homeostasis ex vivo and in vivo. Ecotoxicol. Environ. Saf. 2023, 262, 115347.
(60) Wang, M.; Zhang, Z.; Jing, B.; Dong, X.; Guo, K.; Deng, J.; Wang, Z.; Wan, W.; Jin, W.; Gao, Z.; Liu, Y.*; Tailoring the Amphiphilicity of Fluorescent Protein Chromophores to Detect Intracellular Proteome Aggregation in Diverse Biological Samples. Anal. Chem. 2023, 95, 31, 11751–11760.
(59) Xia, Q.╪; Wang. Z.╪; Wan, W.; Feng, H.; Sun, R.; Jing, B.; Ge, Y.*; Liu, Y.*; Fluorene-based Tau Fibrillation Sensor and Inhibitor with Fluorogenic and Photo-crosslinking Properties. Chem. Commun. 2023, 59, 10008-10011.
(58) Dong, X.╪; Zhang Z.╪; Wan, W,; Jing, B.; Deng, J.; Jin, W.; Shen, D.; Gao, Z.; Liu Y.*; Integrated Imaging and Proteomic Sensors Resolve Proteome Aggregation in Liver Caused by NSAIDs Overdose. ACS Sens. 2023, 8, 6, 2247–2254
.
(57) Jing, B.╪; Li, J.╪; Guo, K.; Zeng, L.; Sui, J.; Zhang, Z.; Wang, Z.; Jin, H.; Sun, J.; Xue, Z.; Zhao, Q.; Wan, W.*; Dong, X.*, Solvatochromic Crystallization Induced Emission Sensors Detect Proteome Aggregation in Stressed Liver Tissues with Hepatic Cancer and Cirrhosis. J. Mater. Chem. B. 2023, 11, 7654-7662.
(56) Shen, D.╪; Zhao, Q.╪; Wang, M.; Zhong, Bo.; Jin, W.; Huang, Y.; Jin, H.; Jing, B.; Wan, W.; Zhang, X.; Zhang, L.*; Liu, Y.*; Developing an Affinity‐based Chemical Proteomics Method to in‐situ Capture Amorphous Aggregated Proteome and Profile its Heterogeneity in Stressed Cells. Anal. Chem. 2023, 95, 15, 6358–6366.
(55) Sun, R.; Zhang, S.; Liu, Y.*; Li, D.*; Chemical probes for investigating protein liquid-liquid phase separation and aggregation. Curr. Opin. Chem. Biol. 2023, 74, 102291.
(54) Bai, Y.; Wan, W.; Huang, Y.; Wu, J.; Liu, L.; Jing, B.; Chen, J.; Zhang, X.*; Liu, Y.*; Tailoring the Positive and Negative Solvatochromism for Chalcone Analogues to Detect Heterozygous Protein Co-aggregation. Chem. Commun. 2023, 59,4016-4019.
(53) Wang, S.; Guan, L.; Sun, Y.; Cui, L.; Guo, S.; Wang, M.; Liu, Y.; Cui, X.; Zhao, F.; Zhang, Y.; Cao, Y.*; An ultra performance liquid chromatography method for transthyretin variants screening and heart failure assisting diagnosis. Clin. Chim. Acta. 2023, 553, 117709.
(52) Sha, Q.╪; Zhang, Y.╪; Wang, M.; Sun, J.; Zhang, Y.; Zhang, X.; Wang, N.; Liu, Y.*; Liu, Y.; Biochemical and Biophysical Properties of a Rare TTRA81V Mutation Causing Mild Transthyretin amyloid cardiomyopathy . ESC Heart Fail. 2023,11: 112–125.
(51) Shen, B.; Liu, L.; Huang, Y.; Wu, J.; Feng, H.; Liu, Y.*; Huang, H.*; Zhang, X.*; Installing hydrogen bonds as a general strategy to control viscosity sensitivity of molecular rotor fluorophores. Aggregate. 2023, 00, e421.
(50) Sun, F.; Yang, J.; Sun, J.; Liu, Y.; Zhang, L.*; Yan, J.*; Structure-based virtual screening for the inhibition and clearance of amyloidosis by small molecules as pharmacological chaperones. Eur. J. Med. Chem. 2023, 9, 100107.
(49) Ma, Q.╪; Wang, M.╪; Huang, Y.; Nie, Y.; Zhang X.; Yang, D.; Wang, Z.; Ding, S.; Qian, N.; Liu, Y.*; Pan, X.*; Identification of a novel transthyretin mutation D39Y in a cardiac amyloidosis patient and its biochemical characterizations. Front. Cardiovasc. Med. 2023, 10:1091183.
2022
(48) Feng, H.╪; Zhao, Q.╪; Zhang, B.; Hu, H.; Liu, M.; Wu, K.; Li, X.; Zhang, X.*; Zhang, L.*; Liu, Y.*; Enabling Photo-Crosslinking and Photo-Sensitizing Properties for Synthetic Fluorescent Protein Chromophores. Angew. Chem. Int. Ed. 2023, 62, e202215215.
(47) Wan, W.╪; Zhao, Q.╪; Jing, B,╪; Peng, C.; Wang, M.; Huang, Y.; Jin, W.; Zhong, B.; Zhang, Z.; Dong, X.; Gao, Z.*; Zhang, L.*; Liu, Y.*; Interrogating the Impact of Aggregation-induced Emission Nanoparticles on in vitro Protein Stability, ex vivo Protein Homeostasis and in vivo Biocompatibility. Aggregate. 2022, 3, e274.
(46) Shen, D.╪; Jin, W.╪; Zhao, Q.╪; Wang, M.; Zhang, B.; Feng, H.; Wan, W.; Bai, Y.; Lyu, H.; Sun, J.; Zhang, L.*; and Liu, Y.*; Covalent Proteome Solvatochromic Proteome Stress Sensor Based on Schiff Base Reaction. Anal. Chem. 2022, 94(41), 14143–14150.
(45) Xia, Q.; Wan, W.; Jin, W.; Huang, Y.; Sun, R.; Wang, M.; Jing, B.; Peng, C.; Dong, X.; Zhang, R.; Gao, Z.; Liu, Y.*; Solvatochromic Cellular Stress Sensors Reveal the Compactness Heterogeneity and Dynamics of Aggregated Proteome. ACS Sens. 2022, 7, 7, 1919–1925.
(44) Sun, R.; Wan, W.; Jin, W.; Bai, Y.; Xia, Q.; Wang, M.; Huang, Y.; Zeng, L.; Sun, J.; Peng, C.; Jing, B.; Liu, Y.*; Derivatizing Nile Red Fluorophores to Quantify the Heterogeneous Polarity upon Protein Aggregation in the Cell. Chem. Commun. 2022, 58, 5407-5410.
(43) Jiang, M.╪; Wang, M.╪; Chai, Y.; Liu, Q.; Lu, Q.; Tao, Z.; Wu, Q.; Ying, X.; Huang, Y.; Nie, Y.; Tang, Y.; Zhang, X.; Liu, Y.*; and Pu, J.*; Biochemical and Biophysical Properties of an Unreported T96R Mutation Causing Transthyretin Cardiac Amyloidosis. Amyloid. 2022, 30:2, 188-198.
(42) Shen, B.; Jung, K.; Ye, S.; Hoelzel, C.; Wolstenholme, C.; Huang, H.*; Liu, Y.*; Zhang, X.*; A dual-functional BODIPY-based molecular rotor probe reveals different viscosity of protein aggregates in live cells. Aggregate. 2022, e301.
(41) Chu, X.╪; Wang, M.╪; Tang, R.╪; Huang, Y.; Yu, J.; Cao, Y.; Zheng, Y.; Xie, Z.; Deng, J.; Wang, Z.; Ma, W.; Song, W.; Wu, Y.; Lv, H.; Zhang, W.; Wang, Z.; Yuan, Y.; Liu, Y.*; Meng, L.*; Clinical and Biochemical Characterizations of Hereditary Transthyretin Amyloidosis Caused by E61K Mutation. Front. Mol. Neurosci. 2022, 15:1003303.
(40) Zhu, M.; Huangfu, C.; Wan, W.; Wang, M.; Lyu, H.; Zhang, X.; Wang, F.; Zhi, H.; Huang, Y.; Chen, M.; Zhao, Z.; Li, C.; Dong, X.; Gao, Z.; Liu, Y.* and Feng, L.*; A Novel Virus Detection Strategy Enabled by TR512-peptide based Bioorthogonal Capture and Enrichment of Preamplified Nucleic Acid. Anal. Chem. 2022, 94 (14), 5591-5598.
(39) Zeng, Q.; Chen, Y.; Yan, Y.; Wan, R.; Li, Y.; Fu, H.*; Liu, Y.; Liu, S.*; Yan X.; and Cui, M.*; D-π-A-Based Trisubstituted Alkenes as Environmentally Sensitive Fluorescent Probes to Detect Lewy Pathologies. Anal. Chem. 2022, 94 (44), 15261-15269.
(38) Guo, Y.╪; Shen, D.╪; Zhou, Y.╪; Yang, Y.╪; Liang, J.; Zhou, Y.; Li, N.; Liu, Y.; Yang, G.*; and Li, W.*; Deep Learning-Based Morphological Classification of Endoplasmic Reticulum Under Stress. Front. Cell Dev. Biol. 2022, 9, 767866.
2021
(37) Wan, W.╪; Zeng, L.╪; Jin, W.; Chen, X.; Shen, D.; Huang, Y.; Wang, M.; Bai, Y.; Lyu, H.; Dong, X.; Gao, Z.; Wang, L.; Liu, X.; Liu, Y.*; A Solvatochromic Fluorescent Probe Reveals Polarity Heterogeneity upon Protein Aggregation in Cells. Angew. Chem. Int. Ed. 2021, 60, 25865-25871.
(36) Shen, D.; Jin, W.; Bai, Y.; Huang, Y.; Lyu, H.; Zeng, L.; Wang, M.; Tang, Y.; Wan, W.; Dong, X.; Gao, Z.; Piao, H.; Liu, X.; Liu, Y.*; Rational Design of Crystallization Induced Emission Probes to Detect Amorphous Protein Aggregation in Live Cells. Angew. Chem. Int. Ed. 2021, 60, 16067-16076.
(35) Wan, W.; Huang, Y.; Xia, Q.; Bai, Y.;Jin, W.;Wang, M.; Lyu, H.; Tang, Y.; Dong, X.; Gao, Z.; Zhao, Q.; Zhang, L.; Liu, Y.*; Covalent Probes for Aggregated Protein Imaging via Michael Addition. Angew. Chem. Int. Ed. 2021, 60, 11335-11343.(Hot paper)
(34) Bai, Y.; Wan, W.*; Huang, Y.; Jin, W.; Lyu, H.; Xia, Q.; Dong, X.; Gao, Z.; Liu, Y.*; Quantitative Interrogation of Protein Co‐aggregation using Multicolor Fluorogenic Protein Aggregation Sensors. Chem.Sci. 2021, 12, 8468–8476. (Most popular 2021 chemical biology articles)
(33) Wan, W.; Jin, W.; Huang, Y.; Xia, Q.; Bai, Y.; Lyu, H.; Liu, D.; Dong, X.; Li, W.*; Liu, Y.*; Monitoring the Dynamics of Proteome Aggregation in Live Cells Using a Solubilized and Noncovalent Analogue of Fluorescent Protein Chromophores. Anal. Chem. 2021, 93(3), 1717-1724.
(32) Bai, Y.; Huang, Y.; Wan, W.; Jin, W.; Shen, D.; Lyu, H.; Zeng, L.; Liu, Y.*; Derivatizing Merocyanine Dyes to Balance Their Polarity and Viscosity Sensitivities for Protein Aggregation Detection. Chem. Commun. 2021, 57, 13313-13316.
(31) Huang, Y.;╪ Bai, Y.;╪ Jin, W.; Shen, D.; Lyu, H.; Zeng, L.; Wang, M.; Liu, Y.*; Common Pitfalls and Recommendations for using Turbidity Assay to Study Protein Phase Separation.Biochemistry. 2021, 60 (32), 2447-2456.
(30) Bai, Y.; Liu, Y.*; Illuminating Protein Phase Separation: Reviewing Aggregation-Induced Emission, Fluorescent Molecular Rotor and Solvatochromic Fluorophore based Probes. Chem. - Eur. J. 2021, 27, 1-14.
(29) Shen, D.; Bai, Y.; Liu, Y.*; Chemical Biology Toolbox to Visualize Protein Aggregation in Live Cells. ChemBioChem. 2022,23,e202100443.
(28) Dong, X.╪; Wan, W.╪; Zeng, L.; Jin, W.; Huang, Y.; Shen, D.; Bai, Y.; Zhao, Q.; Zhang, L.; Liu, Y.* and Gao, Z.*; Regulation of Fluorescence Solvatochromism to Resolve Cellular Polarity upon Protein Aggregation. Anal. Chem. 2021, 93 (49), 16447-16455.
(27) Liu, L.; Jin, W.; Huang, Y.; Dai, J.; Zheng, X.; Liu, Y.; Ju, M.; Shen, B.*; Detecting the Insoluble Protein Aggregates in Live Cells Using an AIE Derivative of Fluorescent Protein Chromophore. Sens. Actuators. B. 2022, 353, 131098.
(26) Liu, J.╪; Xiong, Y.╪; Huang, Y.; Zhu, X.; Liu, Y.; Zhang, L.; Yan, J*; A quinoline–benzothiazole hybrid as the first near-infrared fluorescent probe for transthyretin. New J. Chem. 2021, 45, 18453-18458.
(25) Sun, F.; Liu, J.; Huang, Y.; Zhu, X.; Liu, Y.; Zhang, L.; Yan, J.*; A quinoline derived D-A-D type fluorescent probe for sensing tetrameric transthyretin. Bioorganic Med. Chem. Lett. 2021, 52, 128408.
2020
(24) Wolstenholme, C.; Hu, H.; Ye, S.; Funk, B. E.; Jain, D.; Hsiung, C. H.; Ning, G.; Liu, Y.*; Li, X.*; Zhang, X.*; AggFluor: Fluorogenic Toolbox Enables Direct Visualization of the Multi-Step Protein Aggregation Process in Live Cells. J. Am. Chem. Soc. 2020, 142(41), 17515-17523.
(23) Yu, J.; Li, T.; Liu, Y.; Wang, X.; Zhang, J.*; Wang, X.; Shi, G.; Lou, J; Wang, L.; Wang, C. C.; Wang, L.*; Phosphorylation switches protein disulfide isomerase activity to maintain proteostasis and attenuate ER stress. EMBO J. 2020, e103841
(22) Hoelzel, C., Hu, H., Wolstenholme, C. H.; Karim, B. A.; Munson, K. T.; Jung, K. H.; Zhang, H.; Liu, Y.; Yennawar, H. P.; Asbury, J. B.; Li, X.*; Zhang, X.*; A General Strategy to Enhance Donor‐Acceptor Molecules Using Solvent-Excluding Substituents. Angew Chem Int Ed Engl. 2020, 59, 2-10. (Hot Paper)
Prior to DICP
2019
(21) Kim, S. H.; Liu, Y.; Hoelzel, C.; Zhang, X.*; Lee, T. H.*, Super-Resolution Optical Lithography with DNA. Nano Lett. 2019, 19, 9, 6035-6042.
(20) Jung, K. H.; Kim, S. F.; Liu, Y.; Zhang, X.*, A Fluorogenic AggTag Method Based on Halo- and SNAP-Tags to Simutaneously Detect Aggregation of Two Proteins in Live Cells. ChemBioChem. 2019, 20, 1078-1087.
(19) Liu, Y.; Fares, M.; Zhang, X.*, Monitoring Proteome Stress in Live Cells Using HaloTag-Based Fluorogenic Sensor. Book Chapter, Protein Misfolding Diseases, 2019, Page 171-182.
(18) Jung, K. H.; Fares, M.; Grainger, L. S.; Wolstenholme, C. H.; Hou, A.; Liu, Y.; Zhang, X.*, A SNAP-tag fluorogenic probe mimicking the chromophore of the red fluorescent protein Kaede. Org. Biomol. Chem., 2019, 17(7), 1906-1915.
2018
(17) Liu, Y.; Wolstenholme, C. H.; Carter, G. C.; Liu, H.; Hu, H.; Grainger, L. S.; Miao, K; Fares, M;Hoelzel, C. A.; Yennawar, H. P.; Ning, G.; Du, M.; Bai, L.; Li, X.; Zhang, X.*, Modulation of Fluorescent Protein Chromophores to Detect Protein Aggregation with Turn-on Fluorescence. J. Am. Chem. Soc., 2018, 140(24), 7381-7384. (Highlighted by F1000Prime)
(16) Liu, Y.; Zhang, X.*, Heat Shock Protein Reports on Proteome Stress, Biotechnol. J., 2018, 13, 1800039.
(15) Liu, Y.; Miao, K; Li, Y; Fares, M; Chen, S; Zhang, X.*， A HaloTag-Based Multicolor Fluorogenic Sensor Visualizes and Quantifies Proteome Stress in Live Cells Using Solvatochromic and Molecular Rotor-Based Fluorophores. Biochemistry, 2018, 57, 31, 4663-4674.
(14) Fares, M.; Li, Y.; Liu, Y.; Miao, K.; Gao, Z.; Zhai, Y.; Zhang, X.*, A molecular rotor-based Halo-tag ligand enables a fluorogenic proteome stress sensor to detect protein misfolding in mildly stressed proteome. Bioconjugate Chem. , 2018, 29 (1), pp 215–224.
2017
(13) Liu, Y.; Miao, K.; Dunham, N. P.; Liu, H.; Fares, M.; Boal, A. K.; Li, X.; Zhang, X.*, The Cation-pi Interaction Enables a Halo-Tag Fluorogenic Probe for Fast No-Wash Live Cell Imaging and Gel-Free Protein Quantification. Biochemistry, 2017, 56 (11), 1585-1595. (ACS Editor’s Choice)
(12) Liu, Y.; Fares, M.; Dunham, N. P.; Gao, Z.; Miao, K.; Jiang, X.; Bollinger, S. S.; Boal, A. K.; Zhang, X.*, AgHalo: A Facile Fluorogenic Sensor to Detect Drug Induced Proteome Stress. Angew Chem Int Ed Engl, 2017, 56, 8672-8676. (Highlighted by F1000Prime).
2016
(11) Chen, W.; Kong, L.; Connelly, S.; Dendle, J. M.; Liu, Y.; Wilson, I. A.; Powers, E. T.*; Kelly, J. W.*, Stabilizing the CH2 Domain of an Antibody by Engineering in an Enhanced Aromatic Sequon. ACS Chem. Biol., 2016, 11 (7), 1852-61.
(10) Chen, W.; Dong, J.; Plate, L.; Mortenson, D. E.; Brighty, G. J.; Li, S.; Liu, Y.; Galmozzi, A.; Lee, P. S.; Hulce, J. J.; Cravatt, B. F.; Saez, E.; Powers, E. T.; Wilson, I. A.; Sharpless, K. B.*; Kelly, J. W.*, Arylfluorosulfates Inactivate Intracellular Lipid Binding Protein(s) through Chemoselective SuFEx Reaction with a Binding Site Tyr Residue. J. Am. Chem. Soc., 2016, 138 (23), 7353-64.
(9) Chen, W.; Dong, J.; Li, S.; Liu, Y.; Wang, Y.; Yoon, L.; Wu, P.; Sharpless, K. B.*; Kelly, J. W.*, Synthesis of Sulfotyrosine-Containing Peptides by Incorporating Fluorosulfated Tyrosine Using an Fmoc-Based Solid-Phase Strategy. Angew Chem Int Ed Engl, 2016, 55 (5), 1835-8.
2015
(8) Liu, Y.; Zhang, X.; Chen, W.; Tan, Y. L.; Kelly, J. W.*, Fluorescence Turn-On Folding Sensor To Monitor Proteome Stress in Live Cells. J. Am. Chem. Soc., 2015, 137 (35), 11303-11.
(7) Cho, Y.; Zhang, X.; Pobre, K. F.; Liu, Y.; Powers, D. L.; Kelly, J. W.; Gierasch, L. M.*; Powers, E. T.*, Individual and collective contributions of chaperoning and degradation to protein homeostasis in E. coli. Cell reports, 2015, 11 (2), 321-33.
(6) Baranczak, A.; Liu, Y.; Connelly, S.; Du, W. G.; Greiner, E. R.; Genereux, J. C.; Wiseman, R. L.; Eisele, Y. S.; Bradbury, N. C.; Dong, J.; Noodleman, L.; Sharpless, K. B.; Wilson, I. A.; Encalada, S. E.*; Kelly, J. W.*, A fluorogenic aryl fluorosulfate for intraorganellar transthyretin imaging in living cells and in Caenorhabditis elegans. J. Am. Chem. Soc., 2015, 137 (23), 7404-14.
2014
(5) Zhang, X.; Liu, Y.; Genereux, J. C.; Nolan, C.; Singh, M.; Kelly, J. W.*, Heat-shock response transcriptional program enables high-yield and high-quality recombinant protein production in Escherichia coli. ACS Chem. Biol., 2014, 9 (9), 1945-9; 1. (ACS Editor’s Choice, highlighted in C&EN News, and ACS Chem. Biol.).
(4) Liu, Y.; Zhang, X.; Tan, Y. L.; Bhabha, G.; Ekiert, D. C.; Kipnis, Y.; Bjelic, S.; Baker, D.; Kelly, J. W.*, De novo-designed enzymes as small-molecule-regulated fluorescence imaging tags and fluorescent reporters. J. Am. Chem. Soc., 2014, 136 (38), 13102-5.
(3) Liu, Y.; Tan, Y. L.; Zhang, X.*; Bhabha, G.; Ekiert, D. C.; Genereux, J. C.; Cho, Y.; Kipnis, Y.; Bjelic, S.; Baker, D.; Kelly, J. W.*, Small molecule probes to quantify the functional fraction of a specific protein in a cell with minimal folding equilibrium shifts. Proc. Natl. Acad. Sci. U.S.A., 2014, 111 (12), 4449-54. (highlighted in ACS Chem. Biol.)
2013
(2) Baranczak, A.; Connelly, S.; Liu, Y.; Choi, S.; Grimster, N. P.; Powers, E. T.; Wilson, I. A.; Kelly, J. W.*, Fluorogenic small molecules requiring reaction with a specific protein to create a fluorescent conjugate for biological imaging--what we know and what we need to learn. Biopolymers, 2014, 101 (5), 484-95.
(1) Suh, E. H; Liu, Y.; Connelly, S.; Genereux, J. C.; Wilson, I. A.; Kelly, J. W.*, Stilbene vinyl sulfonamides as fluorogenic sensors of and traceless covalent kinetic stabilizers of transthyretin that prevent amyloidogenesis. J. Am. Chem. Soc., 2013, 135 (47), 17869-80.
